Reply CRT-P

Catalogue: Outside USA


THE SMALLEST CRT PAcemaker in the world1

Reply CRT-P is built on the heritage of Sorin Pacemaker technology - proven in practice.2,3,4 At 11.3 cc in volume, it is the smallest cardiac resynchronization pacemaker in the world.1

Equipped with a suite of intelligent features designed to pro-actively manage comorbidities and improve patient outcome:

  • Sleep Apnea Monitoring (SAM) > allows us to screen for severe Sleep Apnea as well as monitor the evolution of the disease.
  • Dual Sensor Technology > Enables CRT-P patients to exercise safely5


Learn more about about how heart failure patients can benefit from SAM >

This product is not available for sale or distribution in the USA. For further information on product availability, please contact your local representative


WORLD's Smallest CRT-P1...

Reply CRT-P is designed to improve the implant experience and patient comfort:

  • Physiologic shape with gentle curves
  • Allows for a smaller incision and reduced pocket size
  • Better fit for replacements and upgrades


...With no compromise on longevity

> 8 Years Longevity6







Early detection, lifetime monitoring.

SAM is a unique sleep apnea monitoring tool providing automatic screening for the detection of severe sleep apnea. Correlated with the gold standard PSG Apnea Hypopnea Index, SAM is a reliable tool that not allows you to screen patients for severe Sleep Apnea as well as monitor the evolution of the disease3.


SAM has been validated against the gold standard apnea-hypopnea index determined by polysomnography, with high specificity (85%) and high sensitivity (89%)3


Learn more about about how heart failure patients can benefit from SAM >



Provides accurate rate response in CRT

Exercise is proven to have positive effects on mortality, morbidity and quality of life for CRT patients7,8,9.




Exercise improves CRT patients’ NYHA Class10

For CRT patients who are chronotropic incompetent, rate adaptive pacing improves patient outcome.10,11









Enable patients to exercise safely

Dual Sensor technology enables CRT-P patients to exercise safely. It adjusts the heart rate in response to the metabolic need and avoids inappropriate rate increase thanks to its cross-checking technology.


Reply CRT-P Technical Specifications




  1. REPLY CRT-P Implant Manual U636 available at, REPLY CRT-P Technical specs RE6100059 and competition technical manuals (CRT pacemakers) available online.
  2. Stockburger M, Boveda S, Defaye P et al. Longterm clinical effects of ventricular pacing reduction with a changeover mode to minimize ventricular pacing in general population (ANSWER study). EurHeart J. 2015; 36 (3): 151-157.
  3. Defaye P, De la Cruz I, Martí-Almor J, et al. A pacemaker transthoracic impedance sensor with an advanced algorithm to identify severe sleep apnea: The DREAM European study. Heart Rhythm. 2014; 11: 842-8.
  4. Swedish ICD and pacemaker registry, Karolinska Hopital department of cardiology, Sweden, 2013.
  5. Dual sensor technology responds to the metabolic demand of the body via the minute ventilation sensor and avoids any inappropriate reaction from the accelerometer thanks to its cross-checking technology. As a result, Reply CRT-P ensures optimal conditions for exercise training. For more details please refer to the Sorin REPLY CRT-P implant manual (U636 REPLY CRT-P) available at as well as the Tech corner technical document on Dual sensor, available in our medical professionals education section on

  6. Reply CRT-P Implant manual U636 available at / 8.0 years: DDDR, 60 min-1. Pacing amplitude: A=RV=2.5 V, LV= 3 V, 0.35 ms,
    500 Ohms, EGM & Diagnostics ON, MV sensor ON. Pacing percentage A=15%, V=LV=100%.
  7. Conraads VM, Vanderheyden M, Paelinck B, et al. The effect of endurance training on exercise capacity following cardiac resynchronization
    therapy in chronic heart failure patients: a pilot trial, Eur J Cardiovasc Prev Rehabil. 2007;14(1):99-106.
  8. De Maeyer C, Beckers P, Vrints CJ, Conraads VM. Exercise training in chronic heart failure. Ther AdvChronic Dis. 2013; 4(3):105-17.
  9. Tabet JY, Meurin P, Ben Driss A, et al. Benefits of exercice training in cardiac heart failure. Cardiovascular Disease. 2009; 102, 721—730.
  10. Patwala AY, Woods PR, Sharp L, et al. Maximizing Patient Benefit From Cardiac Resynchronization Therapy With the Addition of Structured Exercise Training A Randomized Controlled Study. J Am Coll Cardiol. 2009; 53(25):2332-9.
  11. Tse HF, Siu CW, Lee K, et al. Incremental benefit of Rate adaptive pacing on exercice performance during cardiac resynchronisation therapy. J Am
    Coll Cardiol. 2005; 46(12):2292-7.

Heart Failure & Sleep Apnea


• 75 % of HF patients have Sleep Disordered Breathing (SDB)1.
• Central Sleep Apnea (CSA) is 100 times more common in patients with HF than in the general population.2



• 80 % of patients with moderate to severe Obstructive Sleep Apnea (OSA) are undiagnosed3.
• CSA is “silent” for patients with multiple comorbidities1.



• Both CSA and OSA increase the risk of hospitalization and mortality in HF patients4,5
• CSA and HF have a negative impact on each other5,6.




< SDB + Patient Survival

Impact of SDB on acute HF patient survival4.












< CSA + Heart Failure*

CSA and Heart Failure produces a dangerous combination.




* Adapted fom Jaffe et al . 20135


All implanted HF patients could benefit from Sleep apnea monitoring7,8.




  1. Average of 6 studies:                                                                                                                                                                                              -- 76%: Oldenburg O, Lamp B, Faber L, et al. Sleepdisordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients. Eur J Heart Fail. 2007; 9(3):251-7.                                                                                              -- 71%: Schulz R, Blau A, Börgel J, et al. Sleep apnoea in heart failure, Eur Respir J. 2007; 29(6):1201-5.                                                               -- 61%: MacDonald M, Fang J, Pittman SD, et al. The current prevalence of sleep disordered breathing in congestive heart failure patients treated with betablockers, J Clin Sleep Med. 2008; 4(1):38-42.                                                                                                                                          -- 81%: Paulino A, Damy T, Margarit L, et al. Prevalence of sleep-disordered breathing in a 316-patient French cohort of stable congestive heart failure, Arch Cardiovasc Dis. 2009; 102(3):169-75.                                                                                                                                                -- 84%: Andreas S, Hagenah G, Moller C, et al. Cheyne-Stokes respiration and prognosis in congestive heart failure. Am J Cardiol. 1996; 78:1260–1264.                                                                                                                                                                                                       -- 74%: Bitter T, Langer C, Vogt J, et al. Sleep-disordered Breathing in Patients With Atrial Fibrillation and Normal Systolic Left Ventricular Function, Dtsch Arztebl Int. 2009; 106(10): 164–170.
  2. Floras JS. Transvenous phrenic nerve stimulation for central sleep apnoea in heart failure: chicken or egg? Eur Heart J. 2012; 33, 810–812.
  3. Lee W, Nagubadi S, Kryger MH, et al. Epidemiology of Obstructive Sleep Apnea: a Population-based Perspective. Expert Rev Respir Med. 2008; 2(3):349–364.
  4. Khayat R, Jarjoura D, Porter K, et al. Sleep disordered breathing and post-discharge mortality in patients with acute heart failure. Eur Heart J.
    2015; 10.1093.
  5. Jaffe LM, Kjekshus J, Gottlieb SS, et al. Importance and management of chronic sleep apnoea in cardiology. Eur Heart J. 2013; 34(11):809-15.
  6. Khayat R, Abraham W, Patt B, et al. Central sleep apnea is a predictor of cardiac readmission in hospitalized patient with systolic heart failure. J
    Card Fail. 2012; 18, 534–540.
  7. Kusiak A, Wilinski J, Czarnecka D, et al. Cardiac Resynchronization Therapy Affects Sleep Apnea and Quality of Sleep in Patients With Chronic Heart Failure. Circulation. 2012; 126: A12530.
  8. Sinha AM, Skobel EC, Breithardt EA, et al. Cardiac resynchronization therapy improve CSA and Cheynes-Stoke respiration in patient with chronic
    heart failure. J Am Coll Cardiol. 2004; 44(1):68-71.

This product may not be for sale in your country or your area. For further information on product availability, please contact your local representative