REPLY FAMILY

Catalogue: Outside USA

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a combination of natural behaviors inspired by nature

  • SafeR*: world’s first AAI pacing mode with DDD backup to maintain 99.9% intrinsic conduction and manage all AV block1,2
  • DPlus*: DDD with automatic AVD hysteresis designed to preserve AV conduction
  • Dual sensor rate response designed to physiologically modulate heart rhythm by combining accelerometer and minute ventilation sensors
  • AIDA memory: automatic data analysis with programming advice and comprehensive diagnostics on arrhythmias and AV block events
  • Longevity3*: 10 years’ longevity in the smallest can in the world4
  • Acceleration & AVD shortening*: manage carotid sinus syndrome and vasovagal syncope while preserving patient hemodynamics
  • AF prevention*: designed to reduce AF burden by preventing AF episodes
  • SmartCheck, auto implant detection and other optimized parameters simplify implant and follow-up procedures.

*Available in Reply D and DR

REFERENCES

  1. M. Stockburger, S. Boveda, P. Defaye, J. Moreno on behalf of the ANSWER Investigators. Evaluation of the SafeR Mode in patients with a dual chamber pacemaker indication (ANSWER): Long-term clinical outcome results of the ANSWER trial. European Heart Journal.2014 September.
  2. Davy JM, Hoffmann E, Frey A et al. Near elimination of ventricular pacing in SafeR mode compared to DDD modes: a randomized study of 422 patients. Pacing Clin Electrophysiol 2012;35:392-402.
  3. Reply DR model with SafeR™ mode, 100% A pacing, 1% V pacing, 60 bpm, 2.5 V, 0.35 ms, 500 Ohms, EGM ON, Sensors ON: 10.3 years. REPLY DR Model Volume: 8 cc.
  4. Reply DR Competitive Summary, Sorin Group, ULS4222C, October 2013.

This product is not available for sale or distribution in the USA. For further information on product availability, please contact your local representative

Features


Reply DR includes SAFER, the world’s first pacing mode to promote 99.9% intrinsic conduction1

  • Provides AAI pacing while continuously monitoring AV conduction
  • Ensures DDD pacing when needed for all types of AV block
  • Switches back to AAI mode when possible.

 

INTELLIGENT MANAGEMENT OF AV CONDUCTION2

  • Manages all types of AVB
  • Manages exercise by rapidly switching to DDD if required
  • Manages circadian rhythm by allowing long PR if requested

 

 

 

 


REFERENCES

  1. Anselme, F. et al., 2005, First clinical results of AAIsafeR2, a new mode to prevent ventricular pacing, Heart Rhythm, 2, supp 5, p4-99. Data were obtained using earlier version of the SafeRTM algorithm, AAIsafeR2.
  2. M. Stockburger, S. Boveda, P. Defaye, J. Moreno on behalf of the ANSWER Investigators. Evaluation of the SafeR Mode in patients with a dual chamber pacemaker indication (ANSWER): Long-term clinical outcome results of the ANSWER trial. European Heart Journal.2014 September.

Evidence

Clinical results

  • SafeR significantly reduced Vp compared with the DDD mode (11.5% vs. 93.6%, p<0.001), even after three years. Vp was reduced in SND patients as well as in AVB patients. A 51% risk reduction of HF events was observed with SafeR vs. DDD1
  • SAFER significantly reduced ventricular pacing to a mean of 0.5% and a median of less than 0.1% (n=127) in patients selected for no persistent high degree AV2
  • 90% of sinus node disease and 70% of paroxysmal AV block patients had less than 0.5% pacing (n=117) in patients selected for PR interval < 250 ms at rest3

 

REFERENCES

  1. M. Stockburger, S. Boveda, P. Defaye, J. Moreno on behalf of the ANSWER Investigators. Evaluation of the SafeR Mode in patients with a dual chamber pacemaker indication (ANSWER): Long-term clinical outcome results of the ANSWER trial. European Heart Journal.2014 September.
  2. Davy J. M. et al., 2006, Determining the optimal pacing mode to prevent ventricular pacing: SAVE-R study results, Heart Rhythm, 3, supp 5, pS169, P2-94.
  3. Defaye P. et al., 2006, Impact of pacing indication on AAIsafeR2: efficacy to suppress ventricular pacing, Europace 2006; 8 supp 1, p223-4.

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