SLEEP APNEA MONITORING
Our Sleep apnea monitoring algorithm (SAM) measures respiration pauses and reductions.
- Uses an MV sensor
- Provides reliable, automatic screening to detect severe sleep apnea with high specificity (85%) and high sensitivity (89%)1
- Designed to detect, to count and to report abnormal breathing events during the night2
Sleep apnea monitoring is available in Reply 200 SR and DR.
VALIDATED RESPIRATORY DISTURBANCE INDEX
- Based on 20 years of experience with the minute ventilation sensor
- Measured every night from 00:00 to 05:00 (programmable)2
- Validated against gold standard AHI* (polysomnography)1
*Apnea/hypopnea index = number of events/number of hours of sleep
RELIABLE SCREENING FOR SEVERE SLEEP APNEA
- Automatic messages about abnormal breathing events are detected by the device
- Allows for short and efficient follow up
- A severity threshold is used to indicate the risk of severe sleep apnea syndrome2**
**Depending on the patient profile and/or other symptoms, the physician may engage in dialogue with the patient and include a neurologist or a sleep specialist, as appropriate.
Designed to detect, count, and report abnormal breathing events during the night
6 month trend of RDI during follow-up2
AF burden shown in parallel2***
Intelligent management of AV conduction
Uncessary Rv pacing icreases the risk of AF and HF Hospitalization3,4,5,6,7
- Nearly eliminates ventricular pacing8
- Adds 2 years of device longevity9
- Manages all AV blocks10
SafeR was recently shown to be as safe and effective in AVB patients as in SND patients10,11
***Reply 200 DR only
- Defaye P, de la Cruz I, Martí-Almor J et al. A pacemaker transthoracic impedance sensor with an advanced algorithm to identify severe sleep apnea: The DREAM European study. Heart Rhythm 2014;11:842-8.
- Sorin REPLY 200 Implant Manual (U071A Reply 200 DR / U072A Reply 200 SR) – available at http://www.sorinmanuals.com.
Andersen HR, Nielsen JC, Thomsen PE, et al. Long-term follow-up of patients from a randomized trial of atrial versus
ventricular pacing for sick-sinus syndrome. Lancet. 1997;350:1210-6.
Skanes AC, Krahn AD, Yee R, et al, for the CTOPP Investigators. Progression to chronic atrial fibrillation after pacing:
The Canadian Trial Of Physiologic Pacing. J Am Coll Cardiol. 2001;38:167-72.
Nielsen J, Kristensen L, Andersen H, et al. A randomized comparison of atrial and dual chamber pacing in 177
consecutive patients with sick sinus syndrome. J Am Coll Cardiol. 2003;42:614-23.
Sweeney M, Hellkamp A, Ellenbogen K, et al. Adverse effect of ventricular pacing on heart failure and atrial
fibrillation among patients with normal baseline QRS duration in a clinical trial of pacemaker therapy for sinus node
dysfunction. Circulation. 2003;107:2932-37.
Wilkoff BL, Cook JR, Epstein AE, et al. Dual-chamber pacing or ventricular backup pacing in patients with an
implantable defibrillator: the Dual Chamber and VVI Implantable Defibrillator (DAVID) Trial. JAMA. 2002;288:3115–23.
- Davy JM, Hoffmann E, Frey A et al. Near elimination of ventricular pacing in SafeR mode compared to DDD modes: a randomized study of 422 patients. Pacing Clin Electrophysiol 2012; 35:392-402.
- Benkemoun H, Sacrez J, Lagrange P et al. Optimizing pacemaker longevity with pacing mode and settings programming: results from a pacemaker multicenter registry. Pacing Clin Electrophysiol 2012; 35:403-408.
- M. Stockburger, S. Boveda, P. Defaye, J. Moreno on behalf of the ANSWER Investigators. Evaluation of the SafeR Mode in patients with a dual chamber pacemaker indication (ANSWER): Long-term clinical outcome results of the ANSWER trial. European Heart Journal.2014 September.
- Thibault B et al., 2009, Impact of AV Conduction Disorders on SafeR Mode Performance: CAN-SAVER a Canadian Multi-Center Study, PACE 2009, Volume 32, Issue Supplement s1, pages S231–S235.